Computational Studies towards the Identification of Novel Rhodopsin-Binding Compounds as Chemical Chaperones for Misfolded Opsins

Computational Studies towards the Identification of Novel Rhodopsin-Binding Compounds as Chemical Chaperones for Misfolded Opsins

Accumulation of misfolded and mistrafficked rhodopsin on the endoplasmic reticulum of photoreceptor cells has a pivotal role in the pathogenesis of retinitis pigmentosa and a subset of Leber’s congenital amaurosis. One potential strategy to reduce rhodopsin misfolding and aggregation in these condit...

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Bibliographic Details
Main Authors: Gaia Pasqualetto, Martin Schepelmann, Carmine Varricchio, Elisa Pileggi, Caroline Khogali, Siân R. Morgan, Ian Boostrom, Malgorzata Rozanowska, Andrea Brancale, Salvatore Ferla, Marcella Bassetto
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Molecules
Subjects:
molecular modelling
structure-based virtual screening
molecular dynamics
rhodopsin
small-molecules
severe inherited eye diseases
Online Access:https://www.mdpi.com/1420-3049/25/21/4904

Internet

https://www.mdpi.com/1420-3049/25/21/4904

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