Directed Search of Biologically Active Compounds Among Hydrogenated Isoindolylalkyl(alkylaryl-,aryl-)carboxylic acids with Quinazoline Fragment that Modify the Carbohydrate Metabolism: Design, Synthesis and Modification

Directed Search of Biologically Active Compounds Among Hydrogenated Isoindolylalkyl(alkylaryl-,aryl-)carboxylic acids with Quinazoline Fragment that Modify the Carbohydrate Metabolism: Design, Synthesis and Modification

An effective synthesis of (3H-quinazoline-4-ylidene)hydrazides of N-carboxyalkyl-(arylalkyl-,aryl-)isoindoline-1,3-diones, using activated N-protected aminoacids and 4-hydrazinoquinazoline was proposed in the framework methodology of directed search of hypoglycemic agents (fragment-oriented design,...

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Bibliographic Details
Main Authors: Yulya Victorivna Martynenko, Oleksii Mykolayovich Antypenko, Olexandr Anatolievich Brazhko, Irina Borisivna Labenska, Sergii Ivanovich Kovalenko
Format: Article
Language:English
Published: Slovenian Chemical Society 2019-02-01
Series:Acta Chimica Slovenica
Subjects:
(3Н-quinazoline-4-ylidene)hydrazides of N-carboxyalkyl-(aralkyl-aryl-)-isoindoline-1,3-diones
2-([1,2,4]triazolo[1,5-c]quinazoline-2-yl-)alkyl-(alkaryl-, aryl-)-hydroisoindole-1,3(2H)-diones
directed search
physico-chemical properties
spectral featu
Online Access:https://journals.matheo.si/index.php/ACSi/article/view/4731

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https://journals.matheo.si/index.php/ACSi/article/view/4731

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