Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model

Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model

Accumulation of hyper-phosphorylated and aggregated Tau proteins is a neuropathological hallmark of Alzheimer's Disease (AD) and Tauopathies. AD patient brains also exhibit insulin resistance. Whereas, under normal physiological conditions insulin signaling in the brain mediates plasticity and...

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Bibliographic Details
Main Authors: Antoine Leboucher, Tariq Ahmed, Emilie Caron, Anne Tailleux, Sylvie Raison, Aurélie Joly-Amado, Elodie Marciniak, Kevin Carvalho, Malika Hamdane, Kadiombo Bantubungi, Steve Lancel, Sabiha Eddarkaoui, Raphaelle Caillierez, Emmanuelle Vallez, Bart Staels, Didier Vieau, Detlef Balschun, Luc Buee, David Blum
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Neurobiology of Disease
Subjects:
Tau
Alzheimer's disease
Insulin resistance
THY-Tau22
Transgenic mice
Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119300130

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http://www.sciencedirect.com/science/article/pii/S0969996119300130

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