Altered expression of SIRPγ on the T-cells of relapsing remitting multiple sclerosis and type 1 diabetes patients could potentiate effector responses from T-cells.

Altered expression of SIRPγ on the T-cells of relapsing remitting multiple sclerosis and type 1 diabetes patients could potentiate effector responses from T-cells.

Factors regulating self-antigen directed immune-responses in autoimmunity are poorly understood. Signal regulatory protein gamma (SIRPγ) is a human T-cell specific protein with genetic variants associated with type 1 diabetes (T1D). SIRPγ's function in the immune system remains unclear. We show...

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Main Authors: Sushmita Sinha, Pranav S Renavikar, Michael P Crawford, Scott M Steward-Tharp, Ashley Brate, Eva Tsalikian, Michael Tansey, Ezzatollah T Shivapour, Tracey Cho, John Kamholz, Nitin J Karandikar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0238070

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https://doi.org/10.1371/journal.pone.0238070

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