Physiological and Pathological Brain Activation in the Anesthetized Rat Produces Hemodynamic-Dependent Cortical Temperature Increases That Can Confound the BOLD fMRI Signal

Physiological and Pathological Brain Activation in the Anesthetized Rat Produces Hemodynamic-Dependent Cortical Temperature Increases That Can Confound the BOLD fMRI Signal

Anesthetized rodent models are ubiquitous in pre-clinical neuroimaging studies. However, because the associated cerebral morphology and experimental methodology results in a profound negative brain-core temperature differential, cerebral temperature changes during functional activation are likely to...

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Bibliographic Details
Main Authors: Samuel S. Harris, Luke W. Boorman, Devashish Das, Aneurin J. Kennerley, Paul S. Sharp, Chris Martin, Peter Redgrave, Theodore H. Schwartz, Jason Berwick
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Neuroscience
Subjects:
cortical temperature
cerebral metabolic rate of oxygen
cerebral hemodynamics
sensory stimulation
hypercapnia
seizures
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00550/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00550/full

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