Intelligence Quotient Variability in Klinefelter Syndrome Is Associated With GTPBP6 Expression Under Regulation of X-Chromosome Inactivation Pattern

Intelligence Quotient Variability in Klinefelter Syndrome Is Associated With GTPBP6 Expression Under Regulation of X-Chromosome Inactivation Pattern

Klinefelter syndrome (KS) displays a broad dysmorphological, endocrinological, and neuropsychological clinical spectrum. We hypothesized that the neurocognitive dysfunction present in KS relies on an imbalance in X-chromosome gene expression. Thus, the X-chromosome inactivation (XCI) pattern and neu...

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Bibliographic Details
Main Authors: Luciane Simonetti, Lucas G. A. Ferreira, Angela Cristina Vidi, Janaina Sena de Souza, Ilda S. Kunii, Maria Isabel Melaragno, Claudia Berlim de Mello, Gianna Carvalheira, Magnus R. Dias da Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Genetics
Subjects:
X-chromosome inactivation
Klinefelter syndrome
X-linked genes
intelligence quotient
GTPBP6
gene expression
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.724625/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2021.724625/full

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