MARS: leveraging allelic heterogeneity to increase power of association testing

MARS: leveraging allelic heterogeneity to increase power of association testing

Abstract In standard genome-wide association studies (GWAS), the standard association test is underpowered to detect associations between loci with multiple causal variants with small effect sizes. We propose a statistical method, Model-based Association test Reflecting causal Status (MARS), that fi...

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Bibliographic Details
Main Authors: Farhad Hormozdiari, Junghyun Jung, Eleazar Eskin, Jong Wha J. Joo
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Genome Biology
Subjects:
Association studies
Causal variants
Set-based association analysis
Online Access:https://doi.org/10.1186/s13059-021-02353-8

Internet

https://doi.org/10.1186/s13059-021-02353-8

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