CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer

CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer

Abstract Background DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E. coli AlkB homologs ALKBH2 and ALKBH3 have also been linked to...

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Bibliographic Details
Main Authors: Olafur Andri Stefansson, Stefan Hermanowicz, Jasper van der Horst, Holmfridur Hilmarsdottir, Zuzanna Staszczak, Jon Gunnlaugur Jonasson, Laufey Tryggvadottir, Thorkell Gudjonsson, Stefan Sigurdsson
Format: Article
Language:English
Published: BMC 2017-07-01
Series:BMC Cancer
Subjects:
Breast cancer
ALKBH3
Epigenetics
DNA methylation
DNA repair
Alkylation
Online Access:http://link.springer.com/article/10.1186/s12885-017-3453-8

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http://link.springer.com/article/10.1186/s12885-017-3453-8

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