Regulation of pneumococcal epigenetic and colony phases by multiple two-component regulatory systems.

Streptococcus pneumoniae is well known for phase variation between opaque (O) and transparent (T) colonies within clonal populations. While the O variant is specialized in invasive infection (with a thicker capsule and higher resistance to host clearance), the T counterpart possesses a relatively th...

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Bibliographic Details
Main Authors: Juanjuan Wang, Jing-Wen Li, Jing Li, Yijia Huang, Shaomeng Wang, Jing-Ren Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008417