Secreted phospholipase A<sub>2</sub>-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding

Secreted phospholipase A<sub>2</sub>-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding

<p>Abstract</p> <p>Background</p> <p>Activation of microglia, the primary component of the innate immune response in the brain, is a hallmark of neuroinflammation in neurodegenerative disorders, including Alzheimer’s disease (AD) and other pathological conditions such a...

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Bibliographic Details
Main Authors: Martín Rubén, Cordova Claudia, Nieto Maria L
Format: Article
Language:English
Published: BMC 2012-07-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Secreted phospholipase A<sub>2</sub>-IIA
Proliferation
Phagocytosis
Epidermal growth factor receptor
Online Access:http://www.jneuroinflammation.com/content/9/1/154

Internet

http://www.jneuroinflammation.com/content/9/1/154

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