Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae

Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae

Cationic Mn(III) porphyrin complexes based on MnTM-2-PyP are among the most promising superoxide dismutase (SOD) mimicking compounds being considered as potential anti-inflammatory drugs. We studied four of these active compounds in the yeast Saccharomyces cerevisiae, MnTM-2-PyP, MnTE-2-PyP, MnTnHe...

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Bibliographic Details
Main Authors: Alice Ma Li, Jake Martins, Artak Tovmasyan, Joan S. Valentine, Ines Batinic-Haberle, Ivan Spasojevic, Edith B. Gralla
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Oxidative stress
Lysine synthesis
Methionine synthesis
Mitochondria
Mn(III) N-alkylpyridylporphyrin
SOD mimic
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714001025

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http://www.sciencedirect.com/science/article/pii/S2213231714001025

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