Efficacy of the Quorum Sensing Inhibitor FS10 Alone and in Combination with Tigecycline in an Animal Model of Staphylococcal Infected Wound.

Efficacy of the Quorum Sensing Inhibitor FS10 Alone and in Combination with Tigecycline in an Animal Model of Staphylococcal Infected Wound.

In staphylococci, quorum sensing regulates both biofilm formation and toxin production, moreover it has been demonstrated to be inhibited by RNAIII inhibiting peptide (RIP). Aim our study was to evaluate the in vitro activity and its in vivo efficacy of the combined administration of FS10, a novel R...

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Main Authors: Oriana Simonetti, Oscar Cirioni, Ivana Cacciatore, Leonardo Baldassarre, Fiorenza Orlando, Elisa Pierpaoli, Guendalina Lucarini, Elena Orsetti, Mauro Provinciali, Erika Fornasari, Antonio Di Stefano, Andrea Giacometti, Annamaria Offidani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4890846?pdf=render

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http://europepmc.org/articles/PMC4890846?pdf=render

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