Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease

Huntington disease (HD) is a fatal neurodegenerative movement disorder caused by an expanded CAG repeat in the huntingtin gene (HTT). The mutant huntingtin protein is ubiquitously expressed, but only certain brain regions are affected. The hypothalamus has emerged as an important area of pathology w...

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Bibliographic Details
Main Authors: Jo B. Henningsen, Rana Soylu-Kucharz, Maria Björkqvist, Åsa Petersén
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Heliyon
Subjects:
MCH
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021019113