A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals

A new high-content screening assay of the entire hepatitis B virus life cycle identifies novel antivirals

Background & Aims: Chronic hepatitis B is an incurable disease. Addressing the unmet medical need for therapies has been hampered by a lack of suitable cell culture models to investigate the HBV life cycle in a single experimental setup. We sought to develop a platform suitable to investigat...

Full description

Bibliographic Details
Main Authors: Jaewon Yang, Alexander König, Soonju Park, Eunji Jo, Pil Soo Sung, Seung Kew Yoon, Eva Zusinaite, Denis Kainov, David Shum, Marc Peter Windisch
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:JHEP Reports
Subjects:
HBV
HepG2-NTCP
Entry
Replication
Virion secretion
High-throughput screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555921000720

Similar Items

Similar Items