Opposing Effects of Circadian Clock Genes Bmal1 and Period2 in Regulation of VEGF-Dependent Angiogenesis in Developing Zebrafish

Opposing Effects of Circadian Clock Genes Bmal1 and Period2 in Regulation of VEGF-Dependent Angiogenesis in Developing Zebrafish

Molecular mechanisms underlying circadian-regulated physiological processes remain largely unknown. Here, we show that disruption of the circadian clock by both constant exposure to light and genetic manipulation of key genes in zebrafish led to impaired developmental angiogenesis. A bmal1-specific...

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Bibliographic Details
Main Authors: Lasse Dahl Jensen, Ziquan Cao, Masaki Nakamura, Yunlong Yang, Lars Bräutigam, Patrik Andersson, Yin Zhang, Eric Wahlberg, Toste Länne, Kayoko Hosaka, Yihai Cao
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471200201X

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http://www.sciencedirect.com/science/article/pii/S221112471200201X

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