7-ketocholesterol induces apoptosis of MC3T3-E1 cells associated with reactive oxygen species generation, endoplasmic reticulum stress and caspase-3/7 dependent pathway

7-ketocholesterol induces apoptosis of MC3T3-E1 cells associated with reactive oxygen species generation, endoplasmic reticulum stress and caspase-3/7 dependent pathway

Type 2 diabetes mellitus (T2DM) is associated with an increased risk of bone fractures without reduction of bone mineral density. The cholesterol oxide 7-ketocholesterol (7KCHO) has been implicated in numerous diseases such as atherosclerosis, Alzheimer's disease, Parkinson's disease, canc...

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Bibliographic Details
Main Authors: Yuta Sato, Noriko Ishihara, Daiji Nagayama, Atsuhito Saiki, Ichiro Tatsuno
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
7-ketocholesterol
MC3T3-E1 cells
Reactive oxygen species (ROS)
N-acetylcysteine (NAC)
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426916301161

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http://www.sciencedirect.com/science/article/pii/S2214426916301161

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