The Role of Pancreatic Alpha Cells and Endothelial Cells in the Reduction of Oxidative Stress in Pseudoislets

The Role of Pancreatic Alpha Cells and Endothelial Cells in the Reduction of Oxidative Stress in Pseudoislets

Pancreatic beta cells have inadequate levels of antioxidant enzymes, and the damage induced by oxidative stress poses a challenge for their use in a therapy for patients with type 1 diabetes. It is known that the interaction of the pancreatic endocrine cells with support cells can improve their surv...

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Bibliographic Details
Main Authors: Fredrik C. Wieland, Mireille M.J.P.E. Sthijns, Thomas Geuens, Clemens A. van Blitterswijk, Vanessa L.S. LaPointe
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
GLP-1 - glucagon-like peptide-1
INS1E cells
HUVEC - human umbilical vein endothelial cell line
oxidative stress
pseudoislet
ROS - reactive oxygen species
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.729057/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.729057/full

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