3-Glucosylated 5-amino-1,2,4-oxadiazoles: synthesis and evaluation as glycogen phosphorylase inhibitors

3-Glucosylated 5-amino-1,2,4-oxadiazoles: synthesis and evaluation as glycogen phosphorylase inhibitors

Glycogen phosporylase (GP) is a promising target for the control of glycaemia. The design of inhibitors binding at the catalytic site has been accomplished through various families of glucose-based derivatives such as oxadiazoles. Further elaboration of the oxadiazole aromatic aglycon moiety is now...

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Bibliographic Details
Main Authors: Marion Donnier-Maréchal, David Goyard, Vincent Folliard, Tibor Docsa, Pal Gergely, Jean-Pierre Praly, Sébastien Vidal
Format: Article
Language:English
Published: Beilstein-Institut 2015-04-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
amidoxime
carbodiimide
glycogen phosphorylase
oxadiazole
Vilsmeier salt
Online Access:https://doi.org/10.3762/bjoc.11.56

Internet

https://doi.org/10.3762/bjoc.11.56

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