Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity.

Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity.

The type 2 iodothyronine deiodinase (D2) converts the pro-hormone thyroxine into T3 within target tissues. D2 is essential for a full thermogenic response of brown adipose tissue (BAT), and mice with a disrupted Dio2 gene (D2KO) have an impaired response to cold. BAT is also activated by overfeeding...

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Bibliographic Details
Main Authors: Alessandro Marsili, Cristina Aguayo-Mazzucato, Ting Chen, Aditi Kumar, Mirra Chung, Elaine P Lunsford, John W Harney, Thuy Van-Tran, Elena Gianetti, Waile Ramadan, Cyril Chou, Susan Bonner-Weir, Philip Reed Larsen, Jorge Enrique Silva, Ann Marie Zavacki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3116839?pdf=render

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http://europepmc.org/articles/PMC3116839?pdf=render

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