Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation
Individuals with malignant hyperthermia susceptibility (MHS) suffer from lifethreatening responses to heat. Here the authors demonstrate that adaptive thermogenesis from brown adipose tissue contributes to this heat sensitivity in a preclinical mouse model of MHS
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| Language: | English |
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Nature Publishing Group
2020-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18865-z |
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doaj-1dca01fbb1744c91925d570cd3ada4fa2021-10-10T11:46:49ZengNature Publishing GroupNature Communications2041-17232020-10-0111112010.1038/s41467-020-18865-zAdaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutationHui J. Wang0Chang Seok Lee1Rachel Sue Zhen Yee2Linda Groom3Inbar Friedman4Lyle Babcock5Dimitra K. Georgiou6Jin Hong7Amy D. Hanna8Joseph Recio9Jong Min Choi10Ting Chang11Nadia H. Agha12Jonathan Romero13Poonam Sarkar14Nicol Voermans15M. Waleed Gaber16Sung Yun Jung17Matthew L. Baker18Robia G. Pautler19Robert T. Dirksen20Sheila Riazi21Susan L. Hamilton22Department of Molecular Physiology and Biophysics, Baylor College of MedicineDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineDepartment of Pharmacology and Physiology, University of Rochester Medical CenterDepartment of Anesthesiology, University of TorontoDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineAdvance Technology Core, Mass Spectrometry Proteomics Core, Baylor College of MedicineDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineDepartment of Pediatrics, Baylor College of MedicineDepartment of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical CentreDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineAdvance Technology Core, Mass Spectrometry Proteomics Core, Baylor College of MedicineAdvance Technology Core, Mass Spectrometry Proteomics Core, Baylor College of MedicineDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineDepartment of Pharmacology and Physiology, University of Rochester Medical CenterDepartment of Anesthesiology, University of TorontoDepartment of Molecular Physiology and Biophysics, Baylor College of MedicineIndividuals with malignant hyperthermia susceptibility (MHS) suffer from lifethreatening responses to heat. Here the authors demonstrate that adaptive thermogenesis from brown adipose tissue contributes to this heat sensitivity in a preclinical mouse model of MHShttps://doi.org/10.1038/s41467-020-18865-z |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Hui J. Wang Chang Seok Lee Rachel Sue Zhen Yee Linda Groom Inbar Friedman Lyle Babcock Dimitra K. Georgiou Jin Hong Amy D. Hanna Joseph Recio Jong Min Choi Ting Chang Nadia H. Agha Jonathan Romero Poonam Sarkar Nicol Voermans M. Waleed Gaber Sung Yun Jung Matthew L. Baker Robia G. Pautler Robert T. Dirksen Sheila Riazi Susan L. Hamilton |
| spellingShingle |
Hui J. Wang Chang Seok Lee Rachel Sue Zhen Yee Linda Groom Inbar Friedman Lyle Babcock Dimitra K. Georgiou Jin Hong Amy D. Hanna Joseph Recio Jong Min Choi Ting Chang Nadia H. Agha Jonathan Romero Poonam Sarkar Nicol Voermans M. Waleed Gaber Sung Yun Jung Matthew L. Baker Robia G. Pautler Robert T. Dirksen Sheila Riazi Susan L. Hamilton Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation Nature Communications |
| author_facet |
Hui J. Wang Chang Seok Lee Rachel Sue Zhen Yee Linda Groom Inbar Friedman Lyle Babcock Dimitra K. Georgiou Jin Hong Amy D. Hanna Joseph Recio Jong Min Choi Ting Chang Nadia H. Agha Jonathan Romero Poonam Sarkar Nicol Voermans M. Waleed Gaber Sung Yun Jung Matthew L. Baker Robia G. Pautler Robert T. Dirksen Sheila Riazi Susan L. Hamilton |
| author_sort |
Hui J. Wang |
| title |
Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation |
| title_short |
Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation |
| title_full |
Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation |
| title_fullStr |
Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation |
| title_full_unstemmed |
Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation |
| title_sort |
adaptive thermogenesis enhances the life-threatening response to heat in mice with an ryr1 mutation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-10-01 |
| description |
Individuals with malignant hyperthermia susceptibility (MHS) suffer from lifethreatening responses to heat. Here the authors demonstrate that adaptive thermogenesis from brown adipose tissue contributes to this heat sensitivity in a preclinical mouse model of MHS |
| url |
https://doi.org/10.1038/s41467-020-18865-z |
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