Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation

Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation

Individuals with malignant hyperthermia susceptibility (MHS) suffer from lifethreatening responses to heat. Here the authors demonstrate that adaptive thermogenesis from brown adipose tissue contributes to this heat sensitivity in a preclinical mouse model of MHS

Bibliographic Details
Main Authors: Hui J. Wang, Chang Seok Lee, Rachel Sue Zhen Yee, Linda Groom, Inbar Friedman, Lyle Babcock, Dimitra K. Georgiou, Jin Hong, Amy D. Hanna, Joseph Recio, Jong Min Choi, Ting Chang, Nadia H. Agha, Jonathan Romero, Poonam Sarkar, Nicol Voermans, M. Waleed Gaber, Sung Yun Jung, Matthew L. Baker, Robia G. Pautler, Robert T. Dirksen, Sheila Riazi, Susan L. Hamilton
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18865-z

Internet

https://doi.org/10.1038/s41467-020-18865-z

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