Risk1, a Phosphatidylinositol 3-Kinase Effector, Promotes Rickettsia typhi Intracellular Survival

Risk1, a Phosphatidylinositol 3-Kinase Effector, Promotes Rickettsia typhi Intracellular Survival

Rickettsia species are Gram-negative obligate intracellular bacteria that infect a wide range of eukaryotes and vertebrates. In particular, human body louse-borne Rickettsia prowazekii and flea-borne Rickettsia typhi have historically plagued humankind and continue to reemerge globally. The unavaila...

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Bibliographic Details
Main Authors: Oliver H. Voss, Joseph J. Gillespie, Stephanie S. Lehman, Sherri A. Rennoll, Magda Beier-Sexton, M. Sayeedur Rahman, Abdu F. Azad
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mBio
Subjects:
r. typhi
risk1
rab5
eea1
ubiquitin
beclin-1
lc3b
phagosome escape
endosomal trafficking
phosphoinositide metabolism
autophagosomal maturation
bacterial escape
Online Access:https://doi.org/10.1128/mBio.00820-20

Internet

https://doi.org/10.1128/mBio.00820-20

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