TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells

TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells

Mucin 5AC (MUC5AC) is secreted by goblet cells of the respiratory tract and, surprisingly, also expressed de novo in mucus secreting cancer lines. siRNA-mediated knockdown of 7343 human gene products in a human colonic cancer goblet cell line (HT29-18N2) revealed new proteins, including a Ca2+-activ...

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Bibliographic Details
Main Authors: Sandra Mitrovic, Cristina Nogueira, Gerard Cantero-Recasens, Kerstin Kiefer, José M Fernández-Fernández, Jean-François Popoff, Laetitia Casano, Frederic A Bard, Raul Gomez, Miguel A Valverde, Vivek Malhotra
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-05-01
Series:eLife
Subjects:
Mucin5AC
TRPM5
Secretion
Online Access:https://elifesciences.org/articles/00658

Internet

https://elifesciences.org/articles/00658

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