A <i>SIX6</i> Nonsense Variant in Golden Retrievers with Congenital Eye Malformations

A <i>SIX6</i> Nonsense Variant in Golden Retrievers with Congenital Eye Malformations

Causative genetic variants for more than 30 heritable eye disorders in dogs have been reported. For other clinically described eye disorders, the genetic cause is still unclear. We investigated four Golden Retriever litters segregating for highly variable congenital eye malformations. Several affect...

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Bibliographic Details
Main Authors: Petra Hug, Linda Anderegg, Nicole Dürig, Vincent Lepori, Vidhya Jagannathan, Bernhard Spiess, Marianne Richter, Tosso Leeb
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Genes
Subjects:
<i>Canis lupus familiaris</i>
dog
whole genome sequence
animal model
homeobox
ophthalmology
development
optic nerve
retinal dysplasia
nystagmus
Online Access:https://www.mdpi.com/2073-4425/10/6/454

Internet

https://www.mdpi.com/2073-4425/10/6/454

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