Novel 4-arylaminoquinazolines bearing N,N-diethyl(aminoethyl)amino moiety with antitumour activity as EGFRwt-TK inhibitor

Novel 4-arylaminoquinazolines bearing N,N-diethyl(aminoethyl)amino moiety with antitumour activity as EGFRwt-TK inhibitor

Herein, four novel 4-arylaminoquinazoline derivatives with N,N-diethyl(aminoethyl)amino moiety were designed, synthesised and evaluated on biological activities in vitro. All synthesised compounds have inhibitory effects against tumour cells (SW480, A549, A431 and NCI-H1975). In particular, 4-(3-chl...

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Bibliographic Details
Main Authors: Yaling Zhang, Li Chen, Xiabing Li, Li Gao, Yunxia Hao, Baolin Li, Yaping Yan
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
quinazoline derivatives
n,n-diethyl(aminoethyl)amino moiety
antiproliferative activities
wild type epidermal growth factor receptor tyrosine kinase (egfrwt-tk)
molecular docking
Online Access:http://dx.doi.org/10.1080/14756366.2019.1667341

Internet

http://dx.doi.org/10.1080/14756366.2019.1667341

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