Delivery of Gemcitabine Prodrugs Employing Mesoporous Silica Nanoparticles

Delivery of Gemcitabine Prodrugs Employing Mesoporous Silica Nanoparticles

In this paper, mesoporous silica nanoparticles (MSNs) were studied as vehicles for the delivery of the antitumoral drug gemcitabine (GEM) and of its 4-(N)-acyl derivatives, (4-(N)-valeroyl-(C5GEM), 4-(N)-lauroyl-(C12GEM) and 4-(N)-stearoyl-gemcitabine (C18GEM)). The loading of the GEM lipophilic pro...

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Bibliographic Details
Main Authors: Alessio Malfanti, Ivana Miletto, Emanuela Bottinelli, Daniele Zonari, Giulia Blandino, Gloria Berlier, Silvia Arpicco
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Molecules
Subjects:
mesoporous silica nanoparticles
drug delivery systems
anticancer drugs
prodrugs
biomaterials
surface chemistry
Online Access:http://www.mdpi.com/1420-3049/21/4/522

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http://www.mdpi.com/1420-3049/21/4/522

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