Intracoronary Poloxamer 188 Prevents Reperfusion Injury in a Porcine Model of ST-Segment Elevation Myocardial Infarction

Intracoronary Poloxamer 188 Prevents Reperfusion Injury in a Porcine Model of ST-Segment Elevation Myocardial Infarction

Poloxamer 188 (P188) is a nonionic triblock copolymer believed to prevent cellular injury after ischemia and reperfusion. This study compared intracoronary (IC) infusion of P188 immediately after reperfusion with delayed infusion through a peripheral intravenous catheter in a porcine model of ST-seg...

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Bibliographic Details
Main Authors: Jason A. Bartos, MD, PhD, Timothy R. Matsuura, BA, Adamantios Tsangaris, MD, Matthew Olson, MD, Scott H. McKnite, BS, Jennifer N. Rees, PhD, Karen Haman, PhD, Kadambari Chandra Shekar, MS, Matthias L. Riess, MD, PhD, Frank S. Bates, ScD, Joseph M. Metzger, PhD, Demetris Yannopoulos, MD
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:JACC: Basic to Translational Science
Subjects:
mitochondria
myocardial infarction
poloxamer 188
reperfusion injury
STEMI
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X16300213

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http://www.sciencedirect.com/science/article/pii/S2452302X16300213

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