Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization.

Gene-Targeted Mice with the Human Troponin T R141W Mutation Develop Dilated Cardiomyopathy with Calcium Desensitization.

Most studies of the mechanisms leading to hereditary dilated cardiomyopathy (DCM) have been performed in reconstituted in vitro systems. Genetically engineered murine models offer the opportunity to dissect these mechanisms in vivo. We generated a gene-targeted knock-in murine model of the autosomal...

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Bibliographic Details
Main Authors: Mohun Ramratnam, Guy Salama, Ravi K Sharma, David Wen Rui Wang, Stephen H Smith, Sanjay K Banerjee, Xueyin N Huang, Lindsey M Gifford, Michele L Pruce, Bethann E Gabris, Samir Saba, Sanjeev G Shroff, Ferhaan Ahmad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5147943?pdf=render

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http://europepmc.org/articles/PMC5147943?pdf=render

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