Effervescent N-Acetylcysteine Tablets versus Oral Solution N-Acetylcysteine in Fasting Healthy Adults: An Open-Label, Randomized, Single-Dose, Crossover, Relative Bioavailability Study

Effervescent N-Acetylcysteine Tablets versus Oral Solution N-Acetylcysteine in Fasting Healthy Adults: An Open-Label, Randomized, Single-Dose, Crossover, Relative Bioavailability Study

Background: Oral solution N-acetylcysteine (NAC) is an antidote for acetaminophen overdose, but its unpleasant taste and aroma can impede delivery even after the coadministration of antiemetic medications. Flavored effervescent NAC tablets dissolved in water might be a more palatable formulation tha...

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Bibliographic Details
Main Authors: Spencer C. Greene, MD, FACEP, FACMT, Patrick K. Noonan, PhD, Carlos Sanabria, MD, FACP, W. Frank Peacock, MD, FACEP, FACC
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Current Therapeutic Research
Subjects:
acetaminophen
bioavailability
effervescent tablets
N-acetylcysteine
pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S0011393X16300625

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http://www.sciencedirect.com/science/article/pii/S0011393X16300625

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