Alterations in Sub-Axonal Architecture Between Normal Aging and Parkinson’s Diseased Human Brains Using Label-Free Cryogenic X-ray Nanotomography

Alterations in Sub-Axonal Architecture Between Normal Aging and Parkinson’s Diseased Human Brains Using Label-Free Cryogenic X-ray Nanotomography

Gaining insight to pathologically relevant processes in continuous volumes of unstained brain tissue is important for a better understanding of neurological diseases. Many pathological processes in neurodegenerative disorders affect myelinated axons, which are a critical part of the neuronal circuit...

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Bibliographic Details
Main Authors: Hung Tri Tran, Esther H. R. Tsai, Amanda J. Lewis, Tim Moors, J. G. J. M. Bol, Iman Rostami, Ana Diaz, Allert J. Jonker, Manuel Guizar-Sicairos, Joerg Raabe, Henning Stahlberg, Wilma D. J. van de Berg, Mirko Holler, Sarah H. Shahmoradian
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Neuroscience
Subjects:
human brain
neurodegeneration
Tomography – X-ray computed
Parkinson’s and related diseases
label-free
electron microscograpy
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.570019/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2020.570019/full

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