Fumaric Acid Esters Do Not Reduce Inflammatory NF-κB/p65 Nuclear Translocation, ICAM-1 Expression and T-Cell Adhesiveness of Human Brain Microvascular Endothelial Cells

Fumaric Acid Esters Do Not Reduce Inflammatory NF-κB/p65 Nuclear Translocation, ICAM-1 Expression and T-Cell Adhesiveness of Human Brain Microvascular Endothelial Cells

Dimethyl fumarate (DMF) is approved for disease-modifying treatment of patients with relapsing-remitting multiple sclerosis. Animal experiments suggested that part of its therapeutic effect is due to a reduction of T-cell infiltration of the central nervous system (CNS) by uncertain mechanisms. Here...

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Bibliographic Details
Main Authors: Axel Haarmann, Mathias Nehen, Annika Deiß, Mathias Buttmann
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:International Journal of Molecular Sciences
Subjects:
blood-brain barrier
endothelial cells
multiple sclerosis
dimethyl fumarate
monomethyl fumarate
cell adhesion
NF-κB
p38 mitogen-activated protein kinase
Online Access:http://www.mdpi.com/1422-0067/16/8/19086

Internet

http://www.mdpi.com/1422-0067/16/8/19086

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