Crystal structure of (1S*,2R*)-7-benzyloxy-2-methyl-3-tosyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol: elucidation of the relative configuration of potent allosteric GluN2B selective NMDA receptor antagonists

Crystal structure of (1S*,2R*)-7-benzyloxy-2-methyl-3-tosyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol: elucidation of the relative configuration of potent allosteric GluN2B selective NMDA receptor antagonists

In the title compound, C25H27NO4S, which crystallized as a racemate, the relative configuration of the adjacent OH and CH3 groups on the azepine ring is trans. The seven-membered azepin ring has a chair-like conformation. The planar aromatic rings of the benzyl and tosylate moiety are inclined to th...

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Bibliographic Details
Main Authors: Bastian Tewes, Bastian Frehland, Roland Fröhlich, Bernhard Wünsch
Format: Article
Language:English
Published: International Union of Crystallography 2016-05-01
Series:Acta Crystallographica Section E: Crystallographic Communications
Subjects:
crystal structure
NMDA receptor antagonists
GluN2B antagonists
ifenprodil analogs
tetrahydro-3-benzazepines
relative configuration
conformational restriction
hydrogen bonding
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2056989016005855

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http://scripts.iucr.org/cgi-bin/paper?S2056989016005855

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