NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation

NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation

NMDARs and MAGUK proteins are capable of forming higher-order protein assemblies, however their organisation in the intact brain is unclear. Here, Frank et al. identify mouse and human supercomplexes and discover their mechanism of assembly using genetic tagging and affinity purification.

Bibliographic Details
Main Authors: René A. W. Frank, Noboru H. Komiyama, Tomás J. Ryan, Fei Zhu, Thomas J. O’Dell, Seth G. N. Grant
Format: Article
Language:English
Published: Nature Publishing Group 2016-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11264
Description
Summary:NMDARs and MAGUK proteins are capable of forming higher-order protein assemblies, however their organisation in the intact brain is unclear. Here, Frank et al. identify mouse and human supercomplexes and discover their mechanism of assembly using genetic tagging and affinity purification.
ISSN:2041-1723

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