Hydrophilic Interaction Liquid Chromatography-Electrospray Ionization Mass Spectrometry for Therapeutic Drug Monitoring of Metformin and Rosuvastatin in Human Plasma

Hydrophilic Interaction Liquid Chromatography-Electrospray Ionization Mass Spectrometry for Therapeutic Drug Monitoring of Metformin and Rosuvastatin in Human Plasma

In this work a hydrophilic interaction liquid chromatography/positive ion electrospray mass spectrometric assay (HILIC/ESI-MS) has been developed and fully validated for the quantitation of metformin and rosuvastatin in human plasma. Sample preparation involved the use of 100 μL of human plas...

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Bibliographic Details
Main Authors: Nikolaos Antonopoulos, Giorgos Machairas, George Migias, Ariadni Vonaparti, Vasiliki Brakoulia, Constantinos Pistos, Dimitra Gennimata, Irene Panderi
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Molecules
Subjects:
rosuvastatin
metformin
HILIC
LC-MS
therapeutic drug monitoring
Online Access:http://www.mdpi.com/1420-3049/23/7/1548

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http://www.mdpi.com/1420-3049/23/7/1548

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