Synthesis, Molecular Docking, and Antimycotic Evaluation of Some 3-Acyl Imidazo[1,2-a]pyrimidines

Synthesis, Molecular Docking, and Antimycotic Evaluation of Some 3-Acyl Imidazo[1,2-a]pyrimidines

A series of 3-benzoyl imidazo[1,2-a]pyrimidines, obtained from N-heteroarylformamidines in good yields, was tested in silico and in vitro for binding and inhibition of seven Candida species (Candida albicans (ATCC 10231), Candida dubliniensis (CD36), Candida glabrata (CBS138), Candida guilliermondii...

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Bibliographic Details
Main Authors: Omar Gómez-García, Dulce Andrade-Pavón, Elena Campos-Aldrete, Ricardo Ballinas-Indilí, Alfonso Méndez-Tenorio, Lourdes Villa-Tanaca, Cecilio Álvarez-Toledano
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
3-benzoyl imidazo[1,2-a]pyrimidines
molecular docking
antimycotic activity
Lanosterol 14α-demethylase
Candida spp.
Online Access:http://www.mdpi.com/1420-3049/23/3/599

Internet

http://www.mdpi.com/1420-3049/23/3/599

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