Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis.

Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis.

Photo-activation of psoralen with UVA irradiation, referred to as PUVA, is used in the treatment of proliferative skin disorders. The anti-proliferative effects of PUVA have been largely attributed to psoralen intercalation of DNA, which upon UV treatment, triggers the formation of interstrand DNA c...

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Bibliographic Details
Main Authors: Wenle Xia, David Gooden, Leihua Liu, Sumin Zhao, Erik J Soderblom, Eric J Toone, Wayne F Beyer, Harold Walder, Neil L Spector
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3925176?pdf=render

Internet

http://europepmc.org/articles/PMC3925176?pdf=render

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