Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE

Rh-CSF1 attenuates neuroinflammation via the CSF1R/PLCG2/PKCε pathway in a rat model of neonatal HIE

Abstract Background Hypoxic-ischemic encephalopathy (HIE) is a life-threatening cerebrovascular disease. Neuroinflammation plays an important role in the pathogenesis of HIE, in which microglia are key cellular mediators in the regulation of neuroinflammatory processes. Colony-stimulating factor 1 (...

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Bibliographic Details
Main Authors: Xiao Hu, Shirong Li, Desislava Met Doycheva, Lei Huang, Cameron Lenahan, Rui Liu, Juan Huang, Shucai Xie, Jiping Tang, Gang Zuo, John H. Zhang
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Neuroinflammation
Subjects:
Hypoxic-ischemic encephalopathy
CSF1
CSF1R
PLCG2
Neuroinflammation
Microglia
Online Access:http://link.springer.com/article/10.1186/s12974-020-01862-w

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http://link.springer.com/article/10.1186/s12974-020-01862-w

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