Meso scale discovery-based assays for the detection of aggregated huntingtin.

Meso scale discovery-based assays for the detection of aggregated huntingtin.

Huntington's disease (HD) is a monogenic neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat domain in the huntingtin (HTT) gene, leading to an expanded poly-glutamine (polyQ) stretch in the HTT protein. This mutant HTT (mHTT) protein is highly prone to intracellul...

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Bibliographic Details
Main Authors: Wolfgang Reindl, Barbara Baldo, Jana Schulz, Isabell Janack, Ilka Lindner, Markus Kleinschmidt, Yalda Sedaghat, Christina Thiede, Karsten Tillack, Christina Schmidt, Isabell Cardaun, Tom Schwagarus, Frank Herrmann, Madlen Hotze, Georgina F Osborne, Simone Herrmann, Andreas Weiss, Celina Zerbinatti, Gillian P Bates, Jonathan Bard, Ignacio Munoz-Sanjuan, Douglas Macdonald
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0213521

Internet

https://doi.org/10.1371/journal.pone.0213521

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