Environmental and pharmacological modulations of cellular plasticity: Role in the pathophysiology and treatment of depression

Atrophy of neurons and gross structural alterations of limbic brain regions, including the prefrontal cortex (PFC) and hippocampus, have been reported in brain imaging and postmortem studies of depressed patients. Preclinical findings have suggested that prolonged negative stress can induce changes...

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Bibliographic Details
Main Authors: Kristie T. Ota, Ronald S. Duman
Format: Article
Language:English
Published: Elsevier 2013-09-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002082