Targeting PKC theta in alloreactivity and graft-versus-host-disease: unanswered questions and therapeutic potential

Targeting PKC theta in alloreactivity and graft-versus-host-disease: unanswered questions and therapeutic potential

Protein kinase C isoform theta (PKC theta) is a key modulator of TCR signaling and mediates activation of NF-kappaB, NF-AT and AP-1 transcription factors. Although in vitro studies of PKC theta-/- T cells have shown impaired activation responses, in vivo studies indicate that PKC theta requiremen...

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Bibliographic Details
Main Authors: Crystina eBronk, Xue-Zhong eYu, Amer eBeg
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Immunology
Subjects:
Protein Kinase C
alloreactivity
T cell activation
Anti-tumor effect
graft-versus-host-disease
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00259/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00259/full

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