Monitoring genomic sequences during SELEX using high-throughput sequencing: neutral SELEX.

Monitoring genomic sequences during SELEX using high-throughput sequencing: neutral SELEX.

BACKGROUND: SELEX is a well established in vitro selection tool to analyze the structure of ligand-binding nucleic acid sequences called aptamers. Genomic SELEX transforms SELEX into a tool to discover novel, genomically encoded RNA or DNA sequences binding a ligand of interest, called genomic aptam...

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Bibliographic Details
Main Authors: Bob Zimmermann, Tanja Gesell, Doris Chen, Christina Lorenz, Renée Schroeder
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2820082?pdf=render

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http://europepmc.org/articles/PMC2820082?pdf=render

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