A Thermodynamic Approach for the Prediction of Oiling Out Boundaries from Solubility Data
Many pharmaceutical molecules, fine chemicals, and proteins exhibit liquid−liquid phase separation (LLPS, also known as oiling out) during solution crystallization. LLPS is of significant concern in crystallization process development, as oiling out can compromise the effectiveness of a cr...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-09-01
|
| Series: | Processes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9717/7/9/577 |