USMB-shMincle: a virus-free gene therapy for blocking M1/M2 polarization of tumor-associated macrophages

USMB-shMincle: a virus-free gene therapy for blocking M1/M2 polarization of tumor-associated macrophages

Mincle is essential for tumor-associated macrophage (TAM)-driven cancer progression and represents a potential immunotherapeutic target for cancer. Nevertheless, the lack of a specific inhibitor has largely limited its clinical translation. Here, we successfully developed a gene therapeutic strategy...

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Bibliographic Details
Main Authors: Vivian Weiwen Xue, Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Alex Siu-Wing Chan, Travis Hoi-Wai To, Justin Shing-Yin Chung, Francis Mussal, Eric W.-F. Lam, Chunjie Li, Ka-Fai To, Kam-Tong Leung, Hui-Yao Lan, Patrick Ming-Kuen Tang
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
Mincle
M1/M2 polarization
tumor-associated macrophages
ultrasound microbubble
gene therapy
USMB-shMincle
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770521001212

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http://www.sciencedirect.com/science/article/pii/S2372770521001212

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