Exceptional and Durable Responses to TDM-1 After Trastuzumab Failure for Breast Cancer Skin Metastases: Potential Implications of an Immunological Sanctuary

Exceptional and Durable Responses to TDM-1 After Trastuzumab Failure for Breast Cancer Skin Metastases: Potential Implications of an Immunological Sanctuary

Breast Cancer (BC) skin metastases represent a challenging clinical scenario. Although they usually arise when other distant metastases are already present, they may also represent a form of locoregional recurrence (LRR). Systemic therapy in this setting may have a role both in case a radical locore...

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Bibliographic Details
Main Authors: Tommaso Giarratano, Federica Miglietta, Carlo A. Giorgi, Vassilena Tsvetkova, Silvia Michieletto, Laura Evangelista, Ilaria Polico, Maria V. Dieci, Valentina Guarneri
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Oncology
Subjects:
metastatic breast cancer
skin metastasis
T-DM1
adotrastuzumab
emtansine
immune microenvironment
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00581/full

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https://www.frontiersin.org/article/10.3389/fonc.2018.00581/full

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