Discovery of Potential Anti-infective Therapy Targeting Glutamine Synthetase in Staphylococcus xylosus

Discovery of Potential Anti-infective Therapy Targeting Glutamine Synthetase in Staphylococcus xylosus

Glutamine synthetase (GS), which catalyzes the production of glutamine, plays essential roles in most biological growth and biofilm formation, suggesting that GS may be used as a promising target for antibacterial therapy. We asked whether a GS inhibitor could be found as an anti-infective agent of...

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Bibliographic Details
Main Authors: Wen-Qiang Cui, Qian-Wei Qu, Jin-Peng Wang, Jing-Wen Bai, God'spower Bello-Onaghise, Yu-Ang Li, Yong-Hui Zhou, Xing-Ru Chen, Xin Liu, Si-Di Zheng, Xiao-Xu Xing, Nsabimana Eliphaz, Yan-Hua Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Chemistry
Subjects:
glutamine synthetase
molecular docking
sorafenib
anti-infective
mastitis
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00381/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00381/full

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