Histamine H3 Receptor Antagonist Enhances Neurogenesis and Improves Chronic Cerebral Hypoperfusion-Induced Cognitive Impairments

Histamine H3 Receptor Antagonist Enhances Neurogenesis and Improves Chronic Cerebral Hypoperfusion-Induced Cognitive Impairments

Chronic cerebral hypoperfusion (CCH) is a neurodegenerative disease, which induces cognitive impairments in the central nervous system (CNS). Histamine H3 receptor (H3R) is an autoreceptor involved in the modulation of neurogenesis and synaptic plasticity in the CNS. However, the role of H3R in CCH-...

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Bibliographic Details
Main Authors: Na Wang, Jing Ma, Jing Liu, Jiangong Wang, Cuilan Liu, Hua Wang, Yong Liu, Haijing Yan, Shujun Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
H3R
thioperamide
chronic cerebral hypoperfusion (CCH)
proliferation
cAMP-response element binding
brain-derived neurotrophic factor
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01583/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01583/full

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