c-MYC Expression Is a Possible Keystone in the Colorectal Cancer Resistance to EGFR Inhibitors

c-MYC Expression Is a Possible Keystone in the Colorectal Cancer Resistance to EGFR Inhibitors

Alterations in the transcriptional factor c-MYC could be involved in the anti-EGFR resistance in metastatic colorectal cancer (mCRC). The c-MYC expression was evaluated in 121 RAS and BRAF wild-type mCRC before treatment with anti-EGFR+Folfiri therapy and in 33 subsequent metastases collected during...

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Bibliographic Details
Main Authors: Antonia Strippoli, Alessandra Cocomazzi, Michele Basso, Tonia Cenci, Riccardo Ricci, Francesco Pierconti, Alessandra Cassano, Vincenzo Fiorentino, Carlo Barone, Emilio Bria, Lucia Ricci-Vitiani, Giampaolo Tortora, Luigi Maria Larocca, Maurizio Martini
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
c-myc
colorectal cancer
egfr inhibitor resistance
targeted therapy
Online Access:https://www.mdpi.com/2072-6694/12/3/638

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https://www.mdpi.com/2072-6694/12/3/638

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