IFNγ-producing CD4+ T lymphocytes: the double-edged swords in tuberculosis
Abstract IFNγ-producing CD4+ T cells (IFNγ+CD4+ T cells) are the key orchestrators of protective immunity against Mycobacterium tuberculosis (Mtb). Primarily, these cells act by enabling Mtb-infected macrophages to enforce phagosome-lysosome fusion, produce reactive nitrogen intermediates (RNIs), an...
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| Format: | Article |
| Language: | English |
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Wiley
2017-06-01
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| Series: | Clinical and Translational Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s40169-017-0151-8 |