Isoginkgetin derivative IP2 enhances the adaptive immune response against tumor antigens

Isoginkgetin derivative IP2 enhances the adaptive immune response against tumor antigens

Darrigrand, Pierson et al. study the effect of mRNA splicing inhibitors on the generation of the MHC class I ligands. They developed a derivative of the spliceosome inhibitor isoginkgetin which is less toxic and more effective at enhancing antigen presentation and CD8+ T cell activation and showed g...

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Bibliographic Details
Main Authors: Romain Darrigrand, Alison Pierson, Marine Rouillon, Dolor Renko, Mathilde Boulpicante, David Bouyssié, Emmanuelle Mouton-Barbosa, Julien Marcoux, Camille Garcia, Michael Ghosh, Mouad Alami, Sébastien Apcher
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01801-2

Internet

https://doi.org/10.1038/s42003-021-01801-2

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