Aging and leukemic evolution of hematopoietic stem cells under various stress conditions

Abstract Hematopoietic stem cells (HSCs) have self-renewal capacity and differentiation potential into all lineages of blood cells throughout the lifetime of an organism. The function of HSCs gradually changes during aging. To date, various stress factors influencing HSC aging have been identified....

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Bibliographic Details
Main Authors: Shuhei Kurosawa, Atsushi Iwama
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Inflammation and Regeneration
Subjects:
Online Access:http://link.springer.com/article/10.1186/s41232-020-00138-3